![]() ![]() ![]() Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis. An increased incidence has been seen in patients treated concurrently with cimetidine. Recovery is not influenced by continuation of silver sulfadiazine therapy. Rebound to normal leukocyte levels follows onset within two to three days. Maximal white blood cell depression occurs within two to four days of initiation of therapy. Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy.ġ,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count. The use of silver sulfadiazine cream, USP 1% in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur. However, the incidence of clinically reported fungal superinfection is low. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions which have been associated with sulfonamides are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions, hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Percent of body surface area and the extent of the tissue damage. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the Silver Sulfadiazine Number of Sensitive Strains / ![]() Sulfadiazine Cream, USP 1% Concentration of ![]()
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